• Live Knockout Mice & Conditional Knockout Mice

    GemPharmatech's ambitious Knockout All Project (KOAP) aims to generate KO and cKO mouse strains for all ~23,000 protein coding genes in the mouse genome. Our KO and cKO models can be used in a variety of research fields, including oncology, autoimmunity, metabolism, and neurodegeneration. Using gene editing technology, we have created over 200 Cre mouse strains that were carefully designed for efficient and reliable Cre-driven recombination. These Cre mouse strains supplement our extensive cKO mouse library, allowing for nearly unlimited genetic combinations to fit your research objectives.

    We offer live mice for featured strains to save time for breeding and resuscitation, which can greatly facilitate research needs. The live mice can be shipped in as soon as 2 weeks. The in-stock list below is kept up-to-date and is first come, first served.

    Benefits：

    • Live mice in stock and ready to ship in as soon as two weeks

    • Largest collection of CRISPR mouse strains with over 22,000+ available knockout and conditional knockout mouse model strains with more in development. Free email alerts for the live mice of interests.

    • Access to our comprehensive services platform, including phenotyping, drug efficacy testing, in vitro pathological analysis, and more.

    In-stock List (valid through September 10th, 2023)

    KO & cKO Mice

    Strain ID

    Targeted Gene

    Strain Type

    Background

    Genotype

    Application

    T012747

    		Sting1KOC57BL/6JGptHomozygousViral infections, innate Immunity, autoimmunity, cellular stress and autophagy

    T010873

    		Nlrp3KOC57BL/6JGptHomozygousInnate immunity, inflammatory response

    T005534

    		Ifnar1KOC57BL/6JGptHomozygousViral infection, inflammatory response, oncology-immunity
    T011566Shank3KOC57BL/6JGptHomozygousSynapses, autism
    T003346Trem2KOC57BL/6JGptHeterozygousMetabolic research, protein metabolism, glucose metabolism,homeostasis/metabolism, developmental biology, cell differentiation, immune system, nervous system, physiological system, cardiovascular system, hematopoietic system, cell biology, cell proliferation, cell death, cellular,cell localization, organelles membrane, molecular biology, signal transduction, lipid binding protein, disease and drug evaluation model, neurodegenerative diseases, huntington's disease
    T013709Atp7bKOC57BL/6JGptHeterozygous
    		Metabolic research, protein metabolism, homeostasis/metabolism, developmental biology, growth/size/body, mortality/aging, immune system, nervous system, behavior/neurological, physiological system, integument, pigmentation, muscle, reproductive system, digestive/alimentary system, liver/biliary system, endocrine/exocrine glands, hematopoietic system, cell biology, cellular, cell localization, cytoplasmic vesicle, endoplasmic reticulum, endosome, golgi apparatus, cytomembrane, molecular biology, transporter
    T010437GsdmdKOC57BL/6JGptHomozygousDevelopmental biology, mortality/aging, immune system, physiological system, digestive/alimentary system,hematopoietic system, cell biology, cell death, cellular, cell localization, cell nucleus, organelles membrane, molecular biology, signal transduction, lipid binding protein
    T059534ApcCKOC57BL/6JGptHeterozygousMetabolic research, protein metabolism, homeostasis/metabolism, developmental biology, cell differentiation, embryo,growth/size/body, mortality/aging, immune system, nervous system, vision/eye,hearing/ear, behavior/neurological, synapse, physiological system, integument,pigmentation, cardiovascular system, skeleton,craniofacial, reproductive system, digestive/alimentary system, liver/biliary system, renal/urinary system, endocrine/exocrine glands, hematopoietic system, limbs/digits/tail, cell biology, cell proliferation, cell death, cytoskeleton, cellular, cell nucleus, cytomembrane, organelles membrane, molecular biology, signal transduction, DNA transcription, regulation of enzyme activity
    T007829TREM2ckoC57BL/6JGptHeterozygousMetabolic research, protein metabolism, glucose metabolism, homeostasis/metabolism, developmental biology, cell differentiation, immune system, nervous system, physiological system, cardiovascular system, hematopoietic system, cell biology, cell proliferation, cell death, cellular, cell localization, organelles membrane, molecular biology, signal transduction, lipid binding protein, disease models, neurodegenerative diseases, alzheimer's disease
    T010141Eif2ak3CKOC57BL/6JGptHeterozygousMetabolic research, protein metabolism, homeostasis/metabolism, lipid metabolism, developmental biology, cell differentiation, growth/size/body, mortality/aging, immune system, nervous system, behavior/neurological, physiological system, skeleton, digestive/alimentary system, liver/biliary system, endocrine/exocrine glands, limbs/digits/tail, cell biology, cell death, cellular, cell localization, endoplasmic reticulum, molecular biology,signal transduction, DNA transcription, transferase
    T055933T012667 Ifngr1/T005534 Ifnar1-KO;AG129(B6)CKOC57BL/6JGptHomozygousImmune system
    T013715Cd8a
    		KOC57BL/6JGptHeterozygousDevelopmental biology, cell differentiation, immune system, nervous system, physiological system, hematopoietic system,cell biology, cellular, organelles membrane, molecular biology, signal transduction
    T052653Esr1KOC57BL/6JGptHeterozygousMetabolic research, developmental biology, immune system, integument, cardiovascular system, tumor research,nervous system, signal transduction, skeleton, muscle, respiratory system, adipose tissue, cell proliferation, cell death, DNA transcription, reproductive system, protein metabolism, renal/urinary system, mitochondrial research, physiological system, endocrine/exocrine glands, homeostasis/metabolism, behavior/neurological, cell differentiation, cell biology, molecular biology, cellular, embryo, growth/size/body, hematopoietic system, limbs/digits/tail, mortality/aging, cell localization, lipid metabolism, golgi apparatus, cell nucleus, organelles membrane, synapse, DNA binding protein, lipid binding protein
    T052842Ccr5KOC57BL/6JGptHomozygousMetabolic research, developmental Biology,immune system, cardiovascular system, tumor research, nervous system, signal transduction, vision/eye, cell proliferation, cell death, digestive/alimentary system, liver/biliary system, physiological system, homeostasis/metabolism, behavior/neurological, cell differentiation, cell biology, molecular biology, cellular, hematopoietic system, cell localization, cytoplasmic vesicle, endosome, organelles membrane
    T009945Cpt1aCKOC57BL/6JGptHeterozygousMetabolic research, developmental biology, cardiovascular system, nervous system, signal transduction, vision/eye, reproductive system, mitochondrial research, physiological system, homeostasis/metabolism, cell biology, molecular biology, cellular, mortality/aging, cell localization, lipid metabolism, cytomembrane, transferase
    T011515Pdcd1KOC57BL/6JGptHomozygousDevelopmental biology, immune system, cardiovascular system, tumor research, nervous system, tumor immunity, skeleton, vision/eye, muscle, respiratory system, cell death, digestive/alimentary system, liver/biliary system, renal/urinary system,physiological system, endocrine/exocrine glands, cell biology, cellular, hematopoietic system, mortality/aging, organelles membrane
    T009288Hk2CKOC57BL/6JGptHomozygousMetabolic research,Glucose metabolism,Developmental Biology,embryo,growth/size/body,mortality/aging,nervous system,Cell biology,Cell death,Mitochondrial research,cellular,Cell localization,endoplasmic reticulum,cytomembrane,Organelles membrane,Molecular biology,transferase
    T012963Spp1CKOC57BL/6JGptHeterozygousMetabolic research,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,behavior/neurological,Physiological system,integument,cardiovascular system,skeleton,Muscle ,respiratory system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,Cell biology,Cell death,cellular,Cell localization,Golgi apparatus,Molecular biology,Signal Transduction,DNA transcription
    T029037Zbp1KOC57BL/6JGptHeterozygousimmune system,Cell biology,cellular,cell nucleus,Molecular biology,Signal Transduction,DNA binding protein
    T052591RorcKOC57BL/6JGptHeterozygousMetabolic research,Protein metabolism,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,nervous system,vision/eye,Physiological system,respiratory system,digestive/alimentary system,endocrine/exocrine glands,hematopoietic system,Cell biology,Cell death,cellular,Cell localization,cell nucleus,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein,Lipid binding protein


    Cre Mice

    Strain ID

    Targeted Gene

    Background

    Genotype

    Application

    T004711

    		Adipoq-P2A-iCreC57BL/6JGptHomozygousTheoretically labeled cell type: white adipose tissue, brown adipose tissue

    T004714

    		H11-Vil1-iCre-ployAC57BL/6JGptHomozygousTheoretically labeled cell type: gut epithelial cells

    T050182

    		Rosa26-SA-CreERT2C57BL/6JGptHomozygousExpression system/tissue: whole body (low activity in brain and skeletal muscle)

    T004818

    		Cd4-iCreC57BL/6JGptHomozygousTheoretically labeled cell type: Helper T cells (CD4+ T cells)
    T010829Tg(Prox1-CreERT2)C57BL/6JGptHeterozygousTool mice, Cre/Dre, immune system
    T036859Ckmm-iCre-PolyAC57BL/6JGptHeterozygousCre/Dre, tool mice, adipose tissue, metabolic research
    T052789Lyz2-CreERT2C57BL/6JGptHeterozygousTool Mice, Cre/Dre,immune system

    T009409

    		H11-Stra8-iCreC57BL/6JGptHomozygousTheoretically labeled cell type: seminiferous epithelium, testicular mesenchymal cells, spermatocytes, oogenic cells

    T004985

    		Lyve1-IRES-iCreC57BL/6JGptHeterozygous

    Expressed system/tissue: immune system;

    Theoretically labeled cell type: lymphatic vessel endothelial cells; 

    No cellular level validation performed.

    T006768

    		Cx3cr1-iCreC57BL/6JGptHomozygous

    Expressed system/tissue: immune system (see strain information for details);

    Theoretically labeled cell types: monocytes, macrophages, microglia, NK cells, CD8+ T cells; 

    No cellular level validation performed.

    T050183

    		Rosa26-EIIA-iCreC57BL/6JGptHeterozygous

    Expressed system/tissue: systemic (see strain information for details);

    Theoretically labeled cell type: systemic (expressed early in the embryo, thus achieving systemic expression); 

    No cellular level validation performed.

    T004829H11-Vil1-CreERT2-ployAC57BL/6JGptHeterozygousTool mice, Cre/Dre, physiological system, digestive/alimentary system
    T006205Lrat-P2A-iCreC57BL/6JGptHomozygousTheoretically labeled cell type: hepatic stellate cells
    T050812Upk2-P2A-iCreC57BL/6JGptHeterozygousTool mice, Cre/Dre, physiological system,renal/urinary system
    T052686Cdh5-P2A-CreERT2C57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
    T052686Cdh5-P2A-CreERT2C57BL/6JGptHeterozygousTool mice, Cre/Dre, physiological system,renal/urinary system
    T006806Myf5-P2A-iCreC57BL/6JGptHeterozygousTool mice, Cre/Dre
    T006589S100a4-CreERT2-PolyAC57BL/6JGptHeterozygousTool mice
    T050180Nes-P2A-iCreC57BL/6JGptHeterozygousTool mice, Cre/Dre
    T005636H11-S100a8 (MRP8)-iCreC57BL/6JGptHeterozygousTool mice, Cre/Dre, immune system
    T006950H11-Ctsk-iCreC57BL/6JGptHomozygousMetabolic research, adipose tissue, tool mice, Cre/Dre, physiological system, skeleton, muscle 
    T050766Tmem119-P2A-CreERT2C57BL/6JGptHeterozygousTool mice, Cre/Dre, nervous system
    T004819H11-Itgax-iCreC57BL/6JGptHeterozygousCre/Dre,Tool Mice,immune system
    T004857H11-Gfap-iCreC57BL/6JGptHomozygousCre/Dre,Tool Mice,nervous system
    T004858H11-Myh6-CreERT2C57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,cardiovascular system
    T006862Tagln-iCreC57BL/6JGptHomozygousCre/Dre,Tool Mice,cardiovascular system,Physiological system
    T036801Clec4f-IRES-iCreC57BL/6JGptHomozygousCre/Dre,Tool Mice,immune system
    T049832Spp1-CreERT2-IRES-EGFPC57BL/6JGptHeterozygousTool Mice
    T052681Sp7-iCreC57BL/6JGptHeterozygousTool Mice
    T052699H11-Syn1-iCreC57BL/6JGptHomozygousCre/Dre,Tool Mice,nervous system
    T052797Fos-CreERT2C57BL/6JGptHeterozygousCre/Dre,Tool Mice,nervous system
    T055158Chat-iCreC57BL/6JGptHeterozygous
    		Tool Mice,Cre/Dre
    T058417H11-CAG-LSL-tdTomatoC57BL/6JGptHomozygousTool Mice,Fluorescent protein-labeled mouse,Systemic expression of instrumental proteins,Reporter Mice
    T004833H11-hKRT14-iCreC57BL/6JGptHeterozygousCre/Dre,Tool Mice,integument,Physiological system
    T004859H11-Pax8-CreERT2C57BL/6JGptHomozygousTool Mice,Cre/Dre
    T004861Pvalb-IRES-iCreC57BL/6JGptHeterozygousCre/Dre,Tool Mice,nervous system
    T005328Pf4-P2A-iCreC57BL/6JGptHeterozygousCre/Dre,Tool Mice,immune system
    T007005Cd8a-iCreC57BL/6JGptHeterozygousTool Mice,Cre/Dre,immune system
    T055339Tagln-CreERT2C57BL/6JGptHeterozygousTool Mice,Cre/Dre
    T004822Ins1-iCreC57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,digestive/alimentary system
    T052676Vav1-iCreC57BL/6JGptHeterozygousTool Mice

    Note: The application information of the Cre strains presented above has not been experimentally validated at cellular level.